Gene Information
Gene NameTMPRSS2
OrganismHomo sapiens (Human)
Gene Length492
Protein NamesTransmembrane protease serine 2 (EC 3.4.21.-) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]
Target Nametransmembrane protease serine 2
Target TypeLiterature-reported target
Gene Age950 ( ENSG00000184012 )
Evolutionary StageEumetazoa
AlphaFoldDBO15393
Gene CardTMPRSS2
Uniprot IDO15393
PfamPF15494; PF00089
In ASDno
Allosteric Predictionyes (0.171867064)
Ortholog in AnimalsAlpaca_ TMPRSS2 ( ortholog_one2one )
Dog_ TMPRSS2 ( ortholog_one2one )
Macaque_ TMPRSS2 ( ortholog_one2one )
Mouse_ Tmprss2 ( ortholog_one2one )
Pig_ TMPRSS2 ( ortholog_one2one )
Rat_ Tmprss2 ( ortholog_one2one )
Rabbit_ TMPRSS2 ( ortholog_one2one )
OhnologsPRSS21, TMPRSS4, TMPRSS13, ST14, TMPRSS5, TPSAB1, TMPRSS7, TPSB2
ParalogsTMPRSS15, TMPRSS6, HPN, TMPRSS11E, ST14, TMPRSS3, TMPRSS13, TMPRSS11D, PRSS22, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F
TissueNA
Tissue SpecificityExpressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. Coexpressed with ACE2 within lung type II pneumocytes, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells (Ref.21). {ECO:0000269|PubMed:11169526, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:32404436, ECO:0000269|Ref.21}.
Pharmacological Animal Models0.000730(Chimpanzee);0.001000(Mouse);0.002240(Rat);0.111111(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7MEQ  (X-ray  1.95A  ) 
DBSNP rs12329760  rs775137340  rs1056602  rs779875214  rs200291871  rs75603675 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237};
Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.;
[Transmembrane protease serine 2 catalytic chain]: Secreted {ECO:0000269|PubMed:20382709}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:11245484, ECO:0000269|PubMed:20382709}.
Mouse PG classificationNA
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