| Gene Information | |
|---|---|
| Gene Name | TMPRSS11E |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | Transmembrane protease serine 11E (EC 3.4.21.-) (Serine protease DESC1) (Transmembrane protease serine 11E2) [Cleaved into: Transmembrane protease serine 11E non-catalytic chain; Transmembrane protease serine 11E catalytic chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000087128 ) 3 ( ENSG00000274058 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UL52 |
| Gene Card | TMPRSS11E |
| Uniprot ID | Q9UL52 |
| Pfam | PF01390; PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.826946657) |
| Ortholog in Animals | Alpaca_ TMPRSS11E ( ortholog_one2one ) GuineaPig_ TMPRSS11E ( ortholog_one2one ) Macaque_ TMPRSS11E ( ortholog_one2one ) Mouse_ Tmprss11e ( ortholog_one2one ) Pig_ TMPRSS11E ( ortholog_one2one ) Rat_ Tmprss11e ( ortholog_one2one ) Rabbit_ TMPRSS11E ( ortholog_one2one ) |
| Ohnologs | PRSS21, TMPRSS4, TMPRSS5, TPSAB1 |
| Paralogs | TMPRSS15, TMPRSS6, HPN, ST14, TMPRSS3, TMPRSS13, TMPRSS11D, TMPRSS2, PRSS22, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F |
| Tissue | esophagus, cervix, tongue, esophagus.mucosa, vagina |
| Tissue Specificity | Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis. {ECO:0000269|PubMed:11161383}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2OQ5 (X-ray 1.61A ) |
| DBSNP | rs976002 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q5S248}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5S248}.; [Transmembrane protease serine 11E catalytic chain]: Secreted {ECO:0000250|UniProtKB:Q5S248}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:Q5S248}. |
| Mouse PG classification | NA |
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