| Gene Information | |
|---|---|
| Gene Name | TMEM97 |
| Organism | Homo sapiens (Human) |
| Gene Length | 176 |
| Protein Names | Sigma intracellular receptor 2 (Sigma-2 receptor) (Sigma2 receptor) (Meningioma-associated protein 30) (Transmembrane protein 97) |
| Target Name | sigma intracellular receptor 2 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000109084 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q5BJF2 |
| Gene Card | TMEM97 |
| Uniprot ID | Q5BJF2 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | no (-0.623042589) |
| Ortholog in Animals | Alpaca_ TMEM97 ( ortholog_one2one ) Dog_ TMEM97 ( ortholog_one2one ) GuineaPig_ TMEM97 ( ortholog_one2one ) Macaque_ TMEM97 ( ortholog_one2one ) Mouse_ Tmem97 ( ortholog_one2one ) Pig_ TMEM97 ( ortholog_one2one ) Rabbit_ TMEM97 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells. Highly expressed in various proliferating cancer cells (PubMed:23922215). {ECO:0000269|PubMed:15375745, ECO:0000269|PubMed:18070364, ECO:0000269|PubMed:7694637, ECO:0000303|PubMed:23922215}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus membrane {ECO:0000269|PubMed:19583955}; Multi-pass membrane protein {ECO:0000255}. Rough endoplasmic reticulum membrane {ECO:0000269|PubMed:19583955}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated. {ECO:0000269|PubMed:19583955}. |
| Mouse PG classification | NA |
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