| Gene Information | |
|---|---|
| Gene Name | HAND1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 215 |
| Protein Names | Heart- and neural crest derivatives-expressed protein 1 (Class A basic helix-loop-helix protein 27) (bHLHa27) (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000113196 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O96004 |
| Gene Card | HAND1 |
| Uniprot ID | O96004 |
| Pfam | PF00010 |
| In ASD | no |
| Allosteric Prediction | no (-1.442092934) |
| Ortholog in Animals | Alpaca_ HAND1 ( ortholog_one2one ) Dog_ HAND1 ( ortholog_one2one ) GuineaPig_ HAND1 ( ortholog_one2one ) Macaque_ HAND1 ( ortholog_one2one ) Mouse_ Hand1 ( ortholog_one2one ) Pig_ HAND1 ( ortholog_one2one ) Rat_ Hand1 ( ortholog_one2one ) Rabbit_ HAND1 ( ortholog_one2one ) |
| Ohnologs | HAND2 |
| Paralogs | TWIST2, SCX, PTF1A, FERD3L, BHLHA9, FIGLA, TWIST1, TCF23, HAND2, MSC, TCF15, TCF24, TCF21 |
| Tissue | sigmoid.colon |
| Tissue Specificity | Heart. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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