Gene Information
Gene NameEPPIN
OrganismHomo sapiens (Human)
Gene Length133
Protein NamesEppin (Cancer/testis antigen 71) (CT71) (Epididymal protease inhibitor) (Protease inhibitor WAP7) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000101448 )
Evolutionary StageMammalia
AlphaFoldDBO95925
Gene CardEPPIN;EPPIN-WFDC6
Uniprot IDO95925
PfamPF00014; PF00095
In ASDno
Allosteric Predictionno (-0.944659951)
Ortholog in AnimalsAlpaca_ EPPIN ( ortholog_one2one )
GuineaPig_ EPPIN ( ortholog_one2one )
Macaque_ EPPIN ( ortholog_one2one )
Mouse_ Eppin ( ortholog_one2one )
Pig_ EPPIN ( ortholog_one2one )
Rat_ Eppin ( ortholog_one2one )
OhnologsNA
ParalogsSPINT4, WFIKKN1, KIAA0319, TFPI, SPINT1, TFPI2, AMBP, SPINT2, WFIKKN2, WFDC8, LRP11, KIAA0319L, WFDC6
Tissuetestis
Tissue SpecificityIn testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells. {ECO:0000269|PubMed:11404006, ECO:0000269|PubMed:21461566}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2231838  rs2231839 
Subcellular location [CC][Isoform 1]: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
Mouse PG classificationNA
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