| Gene Information | |
|---|---|
| Gene Name | GPR37 |
| Organism | Homo sapiens (Human) |
| Gene Length | 613 |
| Protein Names | Prosaposin receptor GPR37 (Endothelin B receptor-like protein 1) (ETBR-LP-1) (G-protein coupled receptor 37) (Parkin-associated endothelin receptor-like receptor) (PAELR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000170775 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15354 |
| Gene Card | GPR37 |
| Uniprot ID | O15354 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.117839564) |
| Ortholog in Animals | Alpaca_ GPR37 ( ortholog_one2one ) Dog_ GPR37 ( ortholog_one2one ) GuineaPig_ GPR37 ( ortholog_one2one ) Macaque_ GPR37 ( ortholog_one2one ) Mouse_ Gpr37 ( ortholog_one2one ) Pig_ GPR37 ( ortholog_one2one ) Rat_ Gpr37 ( ortholog_one2one ) Rabbit_ GPR37 ( ortholog_one2one ) |
| Ohnologs | NMBR, GPR37L1 |
| Paralogs | NTSR1, GHSR, NMUR2, NTSR2, GPR39, NMUR1, MLNR, BRS3, NMBR, EDNRA, GRPR, EDNRB, GPR37L1, GPR148, TRHR |
| Tissue | brain, cerebral.cortex, testis |
| Tissue Specificity | Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). {ECO:0000269|PubMed:9526070}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. |
| Mouse PG classification | NA |
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