Gene Information
Gene NamePSTPIP1
OrganismHomo sapiens (Human)
Gene Length416
Protein NamesProline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000140368 )
Evolutionary StageEukaryota
AlphaFoldDBO43586
Gene CardPSTPIP1
Uniprot IDO43586
PfamPF00611; PF14604
In ASDno
Allosteric Predictionno (-0.790165303)
Ortholog in AnimalsAlpaca_ PSTPIP1 ( ortholog_one2one )
Dog_ PSTPIP1 ( ortholog_one2one )
GuineaPig_ PSTPIP1 ( ortholog_one2one )
Macaque_ PSTPIP1 ( ortholog_one2one )
Mouse_ Pstpip1 ( ortholog_one2one )
Pig_ PSTPIP1 ( ortholog_one2one )
Rat_ Pstpip1 ( ortholog_one2one )
OhnologsPSTPIP2
ParalogsPSTPIP2, SGIP1, FCHO2, GAS7, FCHO1
Tissueappendix, bone.marrow, lymph.node, spleen, whole.blood
Tissue SpecificityHighly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta. {ECO:0000269|PubMed:14595024, ECO:0000269|PubMed:9857189}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DIL  (NMR  -  )  7AAL  (X-ray  1.97A  )  7AAM  (X-ray  2.15A  )  7AAN  (X-ray  2.14A  ) 
DBSNP rs1141038  rs1141039  rs1141041  rs1141042  rs1141043  rs1141044  rs1141045  rs121908130  rs28939089  rs28939089 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:9857189}. Cell membrane {ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:9857189};
Peripheral membrane protein {ECO:0000269|PubMed:9857189}. Cell projection, uropodium {ECO:0000269|PubMed:18480402}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19109554, ECO:0000269|PubMed:19584923}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P97814}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P97814}. Cleavage furrow {ECO:0000250|UniProtKB:P97814}. Note=Mainly cytoplasmic in T-cells (PubMed:9857189). Colocalizes in cluster with CD2 near the cell surface membrane in activated T-cells (PubMed:9857189). In monocytes, forms a branched filamentous network in the cytoplasm (PubMed:19584923). In transfected cells, forms relatively straight filaments radiating out from the nucleus (PubMed:19584923). Filament formation requires an intact tubulin cytoskeleton (PubMed:19584923). In migrating neutrophils, colocalizes with PIP5K1C and DNM2 to the trailing edge of the uropod in a actin-dependent manner (PubMed:18480402). Colocalized with PTPN12 in the cytoplasm and the perinuclear region. During interphase, colocalizes with F-actin in the cortical cytoskeleton, lamellipodia, and stress fibers. In dividing cells, colocalizes with the F-actin rich cytokinetic cleavage furrow. Colocalized with CD2AP and WAS in the actin cytoskeleton within the cytoplasm. Colocalized with CD2, CD2AP and WAS at the site of T-cell:APC contact (By similarity). {ECO:0000250|UniProtKB:P97814, ECO:0000269|PubMed:18480402, ECO:0000269|PubMed:19584923, ECO:0000269|PubMed:9857189}.
Mouse PG classificationNA
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