| Gene Information | |
|---|---|
| Gene Name | TMEM251 |
| Organism | Homo sapiens (Human) |
| Gene Length | 163 |
| Protein Names | Lysosomal enzyme trafficking factor (GNPTAB cleavage and activity factor) (GCAF) (Transmembrane protein 251) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000153485 ) 3 ( ENSG00000275947 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N6I4 |
| Gene Card | TMEM251 |
| Uniprot ID | Q8N6I4 |
| Pfam | PF15190 |
| In ASD | no |
| Allosteric Prediction | no (-2.050334374) |
| Ortholog in Animals | Alpaca_ TMEM251 ( ortholog_one2one ) Dog_ TMEM251 ( ortholog_one2one ) GuineaPig_ TMEM251 ( ortholog_one2one ) Macaque_ TMEM251 ( ortholog_one2one ) Mouse_ Tmem251 ( ortholog_one2one ) Pig_ TMEM251 ( ortholog_one2one ) Rat_ Tmem251 ( ortholog_one2one ) Rabbit_ TMEM251 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:33252156, ECO:0000269|PubMed:36074821, ECO:0000269|PubMed:36096887}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GNPTAB and GNPTG in Golgi apparatus cisternae. {ECO:0000269|PubMed:36074821}. |
| Mouse PG classification | NA |
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