| Gene Information | |
|---|---|
| Gene Name | UROD |
| Organism | Homo sapiens (Human) |
| Gene Length | 367 |
| Protein Names | Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) |
| Target Name | uroporphyrinogen decarboxylase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000126088 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P06132 |
| Gene Card | UROD |
| Uniprot ID | P06132 |
| Pfam | PF01208 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999853473) |
| Ortholog in Animals | Alpaca_ UROD ( ortholog_one2one ) Dog_ UROD ( ortholog_one2one ) GuineaPig_ UROD ( ortholog_one2one ) Macaque_ UROD ( ortholog_one2one ) Mouse_ Urod ( ortholog_one2one ) Pig_ UROD ( ortholog_one2one ) Rat_ Urod ( ortholog_one2one ) Rabbit_ UROD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MTR, BHMT2, BHMT, MTHFR |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JPH (X-ray 2.10A ) 1JPI (X-ray 2.30A ) 1JPK (X-ray 2.20A ) 1R3Q (X-ray 1.70A ) 1R3R (X-ray 1.85A ) 1R3S (X-ray 1.65A ) 1R3T (X-ray 1.70A ) 1R3V (X-ray 1.90A ) 1R3W (X-ray 1.70A ) 1R3Y (X-ray 1.75A ) 1URO (X-ray 1.80A ) 2Q6Z (X-ray 2.00A ) 2Q71 (X-ray 1.90A ) 3GVQ (X-ray 2.10A ) 3GVR (X-ray 2.20A ) 3GVV (X-ray 2.80A ) 3GVW (X-ray 2.80A ) 3GW0 (X-ray 2.00A ) 3GW3 (X-ray 1.70A ) |
| DBSNP | rs11541959 rs764268015 rs769378741 rs121918060 rs1131147 rs776907084 rs376921379 rs11541962 rs11541963 rs1182234844 rs762617943 rs121918063 rs121918058 rs143823335 rs121918064 rs982293378 rs141312224 rs36033115 rs1483459837 rs121918057 rs121918057 rs121918059 rs964670864 rs17849533 rs121918065 rs121918061 rs116233118 rs763746230 rs121918066 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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