| Gene Information | |
|---|---|
| Gene Name | MARCHF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 291 |
| Protein Names | E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165406 ) 3 ( ENSG00000278545 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5T0T0 |
| Gene Card | MARCHF8 |
| Uniprot ID | Q5T0T0 |
| Pfam | PF12906 |
| In ASD | no |
| Allosteric Prediction | no (-0.731408313) |
| Ortholog in Animals | Alpaca_ MARCHF8 ( ortholog_one2one ) Dog_ MARCHF8 ( ortholog_one2one ) Macaque_ MARCHF8 ( ortholog_one2one ) Mouse_ Marchf8 ( ortholog_one2one ) Pig_ MARCHF8 ( ortholog_one2one ) Rat_ Marchf8 ( ortholog_one2one ) Rabbit_ MARCHF8 ( ortholog_one2one ) |
| Ohnologs | MARCHF1 |
| Paralogs | MARCHF9, MARCHF4, MARCHF1, MARCHF11, MARCHF3, MARCHF2 |
| Tissue | NA |
| Tissue Specificity | Broadly expressed. Present in immature dendritic cells (at protein level). {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D8S (NMR - ) |
| DBSNP | rs3764990 rs7908745 |
| Subcellular location [CC] | Cytoplasmic vesicle membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |