| Gene Information | |
|---|---|
| Gene Name | ADRA2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 450 |
| Protein Names | Alpha-2B adrenergic receptor (Alpha-2 adrenergic receptor subtype C2) (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor) (Alpha-2BAR) |
| Target Name | adrenergic receptor alpha-2b |
| Target Type | Successful target |
| Gene Age | 886 ( ENSG00000274286 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P18089 |
| Gene Card | ADRA2B |
| Uniprot ID | P18089 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.641103267) |
| Ortholog in Animals | Alpaca_ ADRA2B ( ortholog_one2one ) Dog_ ADRA2B ( ortholog_one2one ) GuineaPig_ ADRA2B ( ortholog_one2one ) Macaque_ ADRA2B ( ortholog_one2one ) Mouse_ Adra2b ( ortholog_one2one ) Pig_ ADRA2B ( ortholog_one2one ) Rat_ Adra2b ( ortholog_one2one ) Rabbit_ ADRA2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OR56A4, ADRA2A, ADRB2, OR56A1, OR56A3, OR56A5, DRD2, ADRA1B, ADRB3, ADRA1D, OR5T2, OR5T3, OR5T1, ADRA1A, GPR101, ADRB1, OR13F1, ADRA2C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6K41 (EM 2.90A ) 6K42 (EM 4.10A ) |
| DBSNP | rs9333568 rs1431850417 rs527655811 rs29000569 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:26811329, ECO:0000269|PubMed:27901063}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096}. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:26811329, ECO:0000269|PubMed:27901063}. |
| Mouse PG classification | LPG |
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