| Gene Information | |
|---|---|
| Gene Name | GCKR |
| Organism | Homo sapiens (Human) |
| Gene Length | 625 |
| Protein Names | Glucokinase regulatory protein (GKRP) (Glucokinase regulator) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000084734 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q14397 |
| Gene Card | GCKR |
| Uniprot ID | Q14397 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | yes (0.832200436) |
| Ortholog in Animals | Alpaca_ GCKR ( ortholog_one2one ) Dog_ GCKR ( ortholog_one2one ) GuineaPig_ GCKR ( ortholog_one2one ) Macaque_ GCKR ( ortholog_one2one ) Mouse_ Gckr ( ortholog_one2one ) Pig_ GCKR ( ortholog_one2one ) Rat_ Gckr ( ortholog_one2one ) Rabbit_ GCKR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | liver |
| Tissue Specificity | Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. {ECO:0000269|PubMed:19643913, ECO:0000269|PubMed:9570959}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4BB9 (X-ray 1.47A ) 4BBA (X-ray 1.92A ) 4LY9 (X-ray 2.35A ) 4MQU (X-ray 2.22A ) 4MRO (X-ray 2.20A ) 4MSU (X-ray 2.50A ) 4OHK (X-ray 2.80A ) 4OHM (X-ray 2.40A ) 4OHO (X-ray 2.58A ) 4OHP (X-ray 2.40A ) 4OLH (X-ray 2.40A ) 4OP1 (X-ray 2.39A ) 4OP2 (X-ray 2.24A ) 4OP3 (X-ray 2.82A ) 4PX2 (X-ray 2.15A ) 4PX3 (X-ray 2.43A ) 4PX5 (X-ray 2.20A ) 4PXS (X-ray 2.60A ) |
| DBSNP | rs8179206 rs8179212 rs1260326 rs8179249 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Mitochondrion {ECO:0000250|UniProtKB:Q07071}. Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}. |
| Mouse PG classification | NA |
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