| Gene Information | |
|---|---|
| Gene Name | SLC22A6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 563 |
| Protein Names | Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1) |
| Target Name | solute carrier family 22 member 6 |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000197901 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q4U2R8 |
| Gene Card | SLC22A6 |
| Uniprot ID | Q4U2R8 |
| Pfam | PF00083 |
| In ASD | no |
| Allosteric Prediction | yes (0.849205007) |
| Ortholog in Animals | Alpaca_ SLC22A6 ( ortholog_one2one ) Dog_ SLC22A6 ( ortholog_one2one ) GuineaPig_ SLC22A6 ( ortholog_one2one ) Macaque_ SLC22A6 ( ortholog_one2one ) Mouse_ Slc22a6 ( ortholog_one2one ) Pig_ SLC22A6 ( ortholog_one2one ) Rat_ Slc22a6 ( ortholog_one2one ) Rabbit_ SLC22A6 ( ortholog_one2one ) |
| Ohnologs | SLC22A2, SLC22A7, SLC22A14, SLC22A3, SLC22A13, SLC22A1 |
| Paralogs | SLC22A24, SLC22A12, SLC22A1, SVOP, SLC22A17, SLC22A7, SLC22A11, SLC22A23, SLC22A2, SLC22A25, SLC22A15, SLC22A9, SLC22A4, SLC22A5, SLC22A3, SLC22A16, SLC22A8, SVOPL, SLC22A31, SLC22A13, SLC22A14, SLC22A10 |
| Tissue | kidney, cortex.of.kidney |
| Tissue Specificity | Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269|PubMed:10049739, ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1415632329 rs11568626 rs11568627 rs45607933 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |