| Gene Information | |
|---|---|
| Gene Name | TMEM120A |
| Organism | Homo sapiens (Human) |
| Gene Length | 343 |
| Protein Names | Ion channel TACAN (Transmembrane protein 120A) (Transmembrane protein induced by tumor necrosis factor alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000189077 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BXJ8 |
| Gene Card | TMEM120A |
| Uniprot ID | Q9BXJ8 |
| Pfam | PF07851 |
| In ASD | no |
| Allosteric Prediction | no (-1.052284587) |
| Ortholog in Animals | Dog_ TMEM120A ( ortholog_one2one ) GuineaPig_ TMEM120A ( ortholog_one2one ) Mouse_ Tmem120a ( ortholog_one2one ) Pig_ TMEM120A ( ortholog_one2one ) Rat_ Tmem120a ( ortholog_one2one ) |
| Ohnologs | TMEM120B |
| Paralogs | TMEM120B |
| Tissue | NA |
| Tissue Specificity | Expressed in nociceptors. {ECO:0000269|PubMed:32084332}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7CXR (EM 3.40A ) 7F3T (EM 3.69A ) 7F3U (EM 4.00A ) 7F6V (EM 3.66A ) 7N7P (EM 3.24A ) |
| DBSNP | rs17852664 rs17855697 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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