| Gene Information | |
|---|---|
| Gene Name | ECE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 770 |
| Protein Names | Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) |
| Target Name | endothelin-converting enzyme 1 |
| Target Type | Literature-reported target |
| Gene Age | 680 ( ENSG00000117298 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P42892 |
| Gene Card | ECE1 |
| Uniprot ID | P42892 |
| Pfam | PF01431; PF05649 |
| In ASD | no |
| Allosteric Prediction | yes (0.510176195) |
| Ortholog in Animals | Alpaca_ ECE1 ( ortholog_one2one ) Dog_ ECE1 ( ortholog_one2one ) GuineaPig_ ECE1 ( ortholog_one2one ) Macaque_ ECE1 ( ortholog_one2one ) Mouse_ Ece1 ( ortholog_one2one ) Pig_ ECE1 ( ortholog_one2one ) Rat_ Ece1 ( ortholog_one2one ) Rabbit_ ECE1 ( ortholog_one2one ) |
| Ohnologs | MMEL1, ECE2, MME |
| Paralogs | KEL, MMEL1, PHEX, MME, ECE2, ECEL1 |
| Tissue | NA |
| Tissue Specificity | All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney. {ECO:0000269|PubMed:10491078, ECO:0000269|PubMed:9396733}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3DWB (X-ray 2.38A ) |
| DBSNP | rs1076669 rs3026906 |
| Subcellular location [CC] | Cell membrane; Single-pass type II membrane protein. |
| Mouse PG classification | NA |
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