| Gene Information | |
|---|---|
| Gene Name | TMED2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 201 |
| Protein Names | Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000086598 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15363 |
| Gene Card | TMED2 |
| Uniprot ID | Q15363 |
| Pfam | PF01105 |
| In ASD | no |
| Allosteric Prediction | no (-0.172427186) |
| Ortholog in Animals | Alpaca_ TMED2 ( ortholog_one2one ) Dog_ TMED2 ( ortholog_one2one ) GuineaPig_ TMED2 ( ortholog_one2one ) Macaque_ TMED2 ( ortholog_one2one ) Mouse_ Tmed2 ( ortholog_one2one ) Rat_ Tmed2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TMED5, TMED1, TMED3, TMED9, TMED6, TMED10, TMED4, TMED7 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.058824(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5AZW (X-ray 1.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:12237308}. |
| Mouse PG classification | NA |
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