| Gene Information | |
|---|---|
| Gene Name | TMCC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 477 |
| Protein Names | Transmembrane and coiled-coil domain protein 3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000057704 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9ULS5 |
| Gene Card | TMCC3 |
| Uniprot ID | Q9ULS5 |
| Pfam | PF10267 |
| In ASD | no |
| Allosteric Prediction | no (-2.006291843) |
| Ortholog in Animals | Alpaca_ TMCC3 ( ortholog_one2one ) Dog_ TMCC3 ( ortholog_one2one ) GuineaPig_ TMCC3 ( ortholog_one2one ) Macaque_ TMCC3 ( ortholog_one2one ) Mouse_ Tmcc3 ( ortholog_one2one ) Pig_ TMCC3 ( ortholog_one2one ) Rat_ Tmcc3 ( ortholog_one2one ) Rabbit_ TMCC3 ( ortholog_one2one ) |
| Ohnologs | TMCC2, TMCC1 |
| Paralogs | TMCC2, TMCC1, TEX28 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in brain, spinal cord and testis. {ECO:0000269|PubMed:27697108}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1274523 rs17854038 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:24454821, ECO:0000269|PubMed:30220460}; Multi-pass membrane protein {ECO:0000255}. Note=Concentrates in discrete patches along peripheral endoplasmic reticulum tubules. {ECO:0000269|PubMed:30220460}. |
| Mouse PG classification | NA |
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