| Gene Information | |
|---|---|
| Gene Name | TMC8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 726 |
| Protein Names | Transmembrane channel-like protein 8 (Epidermodysplasia verruciformis protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000167895 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IU68 |
| Gene Card | TMC8 |
| Uniprot ID | Q8IU68 |
| Pfam | PF07810 |
| In ASD | no |
| Allosteric Prediction | no (-0.819789335) |
| Ortholog in Animals | Alpaca_ TMC8 ( ortholog_one2one ) Dog_ TMC8 ( ortholog_one2one ) GuineaPig_ TMC8 ( ortholog_one2one ) Macaque_ TMC8 ( ortholog_one2one ) Mouse_ Tmc8 ( ortholog_one2one ) Pig_ TMC8 ( ortholog_one2one ) Rat_ Tmc8 ( ortholog_one2one ) |
| Ohnologs | TMC4, TMC5, TMC7 |
| Paralogs | TMC7, TMC4, TMC6, TMC5, TMC2, TMC1, TMC3 |
| Tissue | spleen |
| Tissue Specificity | Expressed in placenta, prostate and testis. {ECO:0000269|PubMed:12906855}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7208422 rs11651675 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12426567}; Multi-pass membrane protein {ECO:0000269|PubMed:12426567}. |
| Mouse PG classification | NA |
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