| Gene Information | |
|---|---|
| Gene Name | MATK |
| Organism | Homo sapiens (Human) |
| Gene Length | 507 |
| Protein Names | Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) |
| Target Name | megakaryocyte-associated tyrosine-protein kinase |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000007264 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P42679 |
| Gene Card | MATK |
| Uniprot ID | P42679 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.404504251) |
| Ortholog in Animals | Alpaca_ MATK ( ortholog_one2one ) Dog_ MATK ( ortholog_one2one ) GuineaPig_ MATK ( ortholog_one2one ) Macaque_ MATK ( ortholog_one2one ) Mouse_ Matk ( ortholog_one2one ) Pig_ MATK ( ortholog_one2one ) Rat_ Matk ( ortholog_one2one ) |
| Ohnologs | CSK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | amygdala, caudate.nucleus, cerebral.cortex, hippocampus, nucleus.accumbens, putamen, whole.blood |
| Tissue Specificity | Expressed in various myeloid cell lines, detected in brain and lung. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.025650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JWO (X-ray 2.50A ) 1X6G (NMR - ) 3US4 (X-ray 1.50A ) |
| DBSNP | rs35351680 rs778726488 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9171348}. Membrane {ECO:0000269|PubMed:9171348}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation. |
| Mouse PG classification | NA |
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