| Gene Information | |
|---|---|
| Gene Name | TMC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 906 |
| Protein Names | Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000149488 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8TDI7 |
| Gene Card | TMC2 |
| Uniprot ID | Q8TDI7 |
| Pfam | PF07810 |
| In ASD | no |
| Allosteric Prediction | no (-0.397887075) |
| Ortholog in Animals | Alpaca_ TMC2 ( ortholog_one2one ) Dog_ TMC2 ( ortholog_one2one ) GuineaPig_ TMC2 ( ortholog_one2one ) Macaque_ TMC2 ( ortholog_one2one ) Mouse_ Tmc2 ( ortholog_one2one ) Pig_ TMC2 ( ortholog_one2one ) Rat_ Tmc2 ( ortholog_one2one ) Rabbit_ TMC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TMC8, TMC7, TMC6, TMC4, TMC5, TMC1, TMC3 |
| Tissue | NA |
| Tissue Specificity | Detected in fetal cochlea. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6050063 rs11908093 rs34884202 rs16987592 rs16987592 rs768537423 rs6115242 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia of the cochlear hair cells. {ECO:0000250|UniProtKB:Q8R4P4}. |
| Mouse PG classification | NA |
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