| Gene Information | |
|---|---|
| Gene Name | TMC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 760 |
| Protein Names | Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165091 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8TDI8 |
| Gene Card | TMC1 |
| Uniprot ID | Q8TDI8 |
| Pfam | PF07810 |
| In ASD | no |
| Allosteric Prediction | no (-0.372256691) |
| Ortholog in Animals | Alpaca_ TMC1 ( ortholog_one2one ) Dog_ TMC1 ( ortholog_one2one ) GuineaPig_ TMC1 ( ortholog_one2one ) Macaque_ TMC1 ( ortholog_one2one ) Mouse_ Tmc1 ( ortholog_one2one ) Pig_ TMC1 ( ortholog_one2one ) Rat_ Tmc1 ( ortholog_one2one ) Rabbit_ TMC1 ( ortholog_one2one ) |
| Ohnologs | TMC3 |
| Paralogs | TMC8, TMC7, TMC6, TMC4, TMC5, TMC2, TMC3 |
| Tissue | NA |
| Tissue Specificity | Detected in fetal cochlea, and at low levels in placenta and testis. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1796993 rs11143384 rs17058153 rs121908072 rs121908074 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q8R4P5}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia of the cochlear hair cells. {ECO:0000250|UniProtKB:Q8R4P5}. |
| Mouse PG classification | HPG |
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