| Gene Information | |
|---|---|
| Gene Name | TM9SF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 663 |
| Protein Names | Transmembrane 9 superfamily member 2 (p76) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000125304 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99805 |
| Gene Card | TM9SF2 |
| Uniprot ID | Q99805 |
| Pfam | PF02990 |
| In ASD | no |
| Allosteric Prediction | no (-0.54960004) |
| Ortholog in Animals | Alpaca_ TM9SF2 ( ortholog_one2one ) Dog_ TM9SF2 ( ortholog_one2one ) GuineaPig_ TM9SF2 ( ortholog_one2one ) Macaque_ TM9SF2 ( ortholog_one2one ) Mouse_ Tm9sf2 ( ortholog_one2one ) Pig_ TM9SF2 ( ortholog_one2one ) Rat_ Tm9sf2 ( ortholog_one2one ) Rabbit_ TM9SF2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TM9SF1, TM9SF3, TM9SF4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Especially abundant in pancreas, highly expressed in kidney, lower levels in heart, brain, skeletal muscle and placenta. Lowest expression in lung and liver. {ECO:0000269|PubMed:9729438}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endosome membrane {ECO:0000305|PubMed:9729438}; Multi-pass membrane protein {ECO:0000255}. Golgi outpost {ECO:0000250|UniProtKB:Q66HG5}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q66HG5}. Note=Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250|UniProtKB:Q66HG5}. |
| Mouse PG classification | NA |
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