| Gene Information | |
|---|---|
| Gene Name | TM7SF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (Another new gene 1 protein) (C-14 sterol reductase) (C14SR) (Putative sterol reductase SR-1) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000149809 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O76062 |
| Gene Card | TM7SF2 |
| Uniprot ID | O76062 |
| Pfam | PF01222 |
| In ASD | no |
| Allosteric Prediction | yes (0.117393272) |
| Ortholog in Animals | Alpaca_ TM7SF2 ( ortholog_one2one ) Dog_ TM7SF2 ( ortholog_one2one ) GuineaPig_ TM7SF2 ( ortholog_one2one ) Macaque_ TM7SF2 ( ortholog_one2one ) Mouse_ Tm7sf2 ( ortholog_one2one ) Pig_ TM7SF2 ( ortholog_one2one ) Rat_ Tm7sf2 ( ortholog_one2one ) |
| Ohnologs | LBR |
| Paralogs | LBR, DHCR7 |
| Tissue | NA |
| Tissue Specificity | Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, testis and adrenal gland, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes. {ECO:0000269|PubMed:16784888, ECO:0000269|PubMed:9878250}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003212(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11539360 rs1129195 |
| Subcellular location [CC] | Microsome membrane {ECO:0000250|UniProtKB:Q71KT5}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9878250}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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