| Gene Information | |
|---|---|
| Gene Name | TM6SF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | Transmembrane 6 superfamily member 2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000213996 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9BZW4 |
| Gene Card | TM6SF2 |
| Uniprot ID | Q9BZW4 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.956583776) |
| Ortholog in Animals | Alpaca_ TM6SF2 ( ortholog_one2one ) Dog_ TM6SF2 ( ortholog_one2one ) GuineaPig_ TM6SF2 ( ortholog_one2one ) Macaque_ TM6SF2 ( ortholog_one2one ) Mouse_ Tm6sf2 ( ortholog_one2one ) Pig_ TM6SF2 ( ortholog_one2one ) Rat_ Tm6sf2 ( ortholog_one2one ) |
| Ohnologs | TM6SF1 |
| Paralogs | TM6SF1 |
| Tissue | duodenum, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Substantial expression in liver and intestine, whereas all other tissues analyzed show low levels. {ECO:0000269|PubMed:25566323}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs58542926 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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