| Gene Information | |
|---|---|
| Gene Name | TLR9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1032 |
| Protein Names | Toll-like receptor 9 (CD antigen CD289) |
| Target Name | toll-like receptor 9 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000239732 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NR96 |
| Gene Card | TLR9 |
| Uniprot ID | Q9NR96 |
| Pfam | PF18837; PF13516; PF13855; PF01582 |
| In ASD | yes |
| Allosteric Prediction | yes (1.133704088) |
| Ortholog in Animals | Alpaca_ TLR9 ( ortholog_one2one ) Dog_ TLR9 ( ortholog_one2one ) GuineaPig_ TLR9 ( ortholog_one2one ) Macaque_ TLR9 ( ortholog_one2one ) Mouse_ Tlr9 ( ortholog_one2one ) Pig_ TLR9 ( ortholog_one2one ) Rat_ Tlr9 ( ortholog_one2one ) Rabbit_ TLR9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LRRC70, LRFN2, LRFN5, SLITRK3, LRFN4, GP5, SLITRK2, LINGO1, TPBGL, SLITRK6, LRFN1, LRRN1, SLITRK1, LRTM2, SLIT3, LRRN2, LRRN3, SLIT2, LRRC38, SLITRK4, LINGO2, SLIT1, SLITRK5, LRRC55, LRFN3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs5743842 rs5743843 rs5743845 rs5743846 rs755472700 rs746622200 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EQU3}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EQU3}. Endosome {ECO:0000250|UniProtKB:Q9EQU3}. Lysosome {ECO:0000250|UniProtKB:Q9EQU3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9EQU3}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. {ECO:0000250|UniProtKB:Q9EQU3}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |