| Gene Information | |
|---|---|
| Gene Name | TLR8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1041 |
| Protein Names | Toll-like receptor 8 (CD antigen CD288) |
| Target Name | toll-like receptor 8 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000101916 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NR97 |
| Gene Card | TLR8 |
| Uniprot ID | Q9NR97 |
| Pfam | PF13855; PF01582 |
| In ASD | no |
| Allosteric Prediction | yes (0.632127886) |
| Ortholog in Animals | Alpaca_ TLR8 ( ortholog_one2one ) GuineaPig_ TLR8 ( ortholog_one2one ) Macaque_ TLR8 ( ortholog_one2one ) Mouse_ Tlr8 ( ortholog_one2one ) Pig_ TLR8 ( ortholog_one2one ) Rat_ Tlr8 ( ortholog_one2one ) Rabbit_ TLR8 ( ortholog_one2one ) |
| Ohnologs | TLR4, TLR3 |
| Paralogs | CD180, RXFP1, NRROS, TLR5, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | appendix, spleen, lymph.node, lung, whole.blood |
| Tissue Specificity | Expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells. {ECO:0000269|PubMed:33718825}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3W3G (X-ray 2.30A ) 3W3J (X-ray 2.00A ) 3W3K (X-ray 2.30A ) 3W3L (X-ray 2.33A ) 3W3M (X-ray 2.70A ) 3W3N (X-ray 2.10A ) 3WN4 (X-ray 1.81A ) 4QBZ (X-ray 2.00A ) 4QC0 (X-ray 2.10A ) 4R07 (X-ray 2.00A ) 4R08 (X-ray 2.40A ) 4R09 (X-ray 2.62A ) 4R0A (X-ray 1.90A ) 4R6A (X-ray 2.10A ) 5AWA (X-ray 2.20A ) 5AWB (X-ray 2.10A ) 5AWC (X-ray 2.50A ) 5AWD (X-ray 2.05A ) 5AZ5 (X-ray 2.40A ) 5HDH (X-ray 2.60A ) 5WYX (X-ray 2.40A ) 5WYZ (X-ray 2.30A ) 5Z14 (X-ray 2.80A ) 5Z15 (X-ray 2.90A ) 6KYA (X-ray 2.89A ) 6TY5 (X-ray 2.79A ) 6V9U (X-ray 2.65A ) 6WML (X-ray 2.50A ) 6ZJZ (X-ray 2.49A ) 7CRF (X-ray 2.89A ) 7R52 (X-ray 2.94A ) 7R53 (X-ray 3.12A ) 7R54 (X-ray 2.84A ) 7RC9 (X-ray 2.76A ) |
| DBSNP | rs5744077 rs5744082 |
| Subcellular location [CC] | Endosome membrane {ECO:0000269|PubMed:25297876}; Single-pass type I membrane protein {ECO:0000250}. Note=Endosomal localization confers distinctive proteolytic processing. {ECO:0000269|PubMed:25297876}. |
| Mouse PG classification | NA |
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