| Gene Information | |
|---|---|
| Gene Name | TLR7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1049 |
| Protein Names | Toll-like receptor 7 |
| Target Name | toll-like receptor 7 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000196664 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NYK1 |
| Gene Card | TLR7 |
| Uniprot ID | Q9NYK1 |
| Pfam | PF13306; PF13855; PF01582 |
| In ASD | no |
| Allosteric Prediction | yes (0.991114156) |
| Ortholog in Animals | Alpaca_ TLR7 ( ortholog_one2one ) Dog_ TLR7 ( ortholog_one2one ) GuineaPig_ TLR7 ( ortholog_one2one ) Macaque_ TLR7 ( ortholog_one2one ) Mouse_ Tlr7 ( ortholog_one2one ) Pig_ TLR7 ( ortholog_one2one ) Rat_ Tlr7 ( ortholog_one2one ) |
| Ohnologs | TLR2, TLR3 |
| Paralogs | CD180, RXFP1, TLR8, NRROS, TLR5, TSKU, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | NA |
| Tissue Specificity | Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Expressed in peripheral mononuclear blood cells (PubMed:32706371). {ECO:0000269|PubMed:32706371}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7CYN (EM 4.20A ) |
| DBSNP | rs179008 rs5743781 rs200553089 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P58681}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P58681}. Endosome {ECO:0000250|UniProtKB:P58681}. Lysosome {ECO:0000250|UniProtKB:P58681}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P58681}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250|UniProtKB:P58681}. |
| Mouse PG classification | NA |
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