| Gene Information | |
|---|---|
| Gene Name | TLR6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 796 |
| Protein Names | Toll-like receptor 6 (CD antigen CD286) |
| Target Name | toll-like receptor 6 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000174130 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y2C9 |
| Gene Card | TLR6 |
| Uniprot ID | Q9Y2C9 |
| Pfam | PF13855; PF01463; PF01582 |
| In ASD | no |
| Allosteric Prediction | no (-0.014217194) |
| Ortholog in Animals | GuineaPig_ TLR6 ( ortholog_one2one ) Macaque_ TLR6 ( ortholog_one2one ) Mouse_ Tlr6 ( ortholog_one2one ) Pig_ TLR6 ( ortholog_one2one ) Rat_ Tlr6 ( ortholog_one2one ) Rabbit_ TLR6 ( ortholog_one2one ) |
| Ohnologs | TLR2 |
| Paralogs | CD180, RXFP1, TLR8, NRROS, TLR5, TSKU, TLR7, TLR10, RXFP2, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, TLR1, LRRC3C, LRRC3, LRIT2 |
| Tissue | NA |
| Tissue Specificity | Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4OM7 (X-ray 2.20A ) |
| DBSNP | rs5743808 rs137853178 rs5743809 rs137853180 rs137853179 rs35220466 rs5743810 rs137853181 rs3796508 rs5743813 rs5743815 rs137853182 rs5743816 rs5743817 rs1302799168 rs75244616 rs114855575 rs137853183 rs5743822 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20037584}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPW9}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus (PubMed:16880211). {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:20037584}. |
| Mouse PG classification | NA |
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