| Gene Information | |
|---|---|
| Gene Name | TLK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 766 |
| Protein Names | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) |
| Target Name | serine/threonine-protein kinase tousled-like 1 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000198586 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UKI8 |
| Gene Card | TLK1 |
| Uniprot ID | Q9UKI8 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.31600687) |
| Ortholog in Animals | Alpaca_ TLK1 ( ortholog_one2one ) Dog_ TLK1 ( ortholog_one2one ) GuineaPig_ TLK1 ( ortholog_one2one ) Macaque_ TLK1 ( ortholog_one2one ) Mouse_ Tlk1 ( ortholog_one2one ) Pig_ TLK1 ( ortholog_one2one ) Rat_ Tlk1 ( ortholog_one2one ) Rabbit_ TLK1 ( ortholog_one2one ) |
| Ohnologs | TLK2 |
| Paralogs | TLK2, TTK |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. {ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:9427565}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:9427565}. |
| Mouse PG classification | NA |
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