| Gene Information | |
|---|---|
| Gene Name | TL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 251 |
| Protein Names | Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O95150 |
| Gene Card | TNFSF15 |
| Uniprot ID | O95150 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. {ECO:0000269|PubMed:11911831, ECO:0000269|PubMed:11923219, ECO:0000269|PubMed:9434163, ECO:0000269|PubMed:9872942}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2O0O (X-ray 3.00A ) 2QE3 (X-ray 2.50A ) 2RE9 (X-ray 2.10A ) 2RJK (X-ray 2.30A ) 2RJL (X-ray 2.05A ) 3K51 (X-ray 2.45A ) 3MI8 (X-ray 2.95A ) |
| DBSNP | rs16931745 |
| Subcellular location [CC] | Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}.; [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted. |
| Mouse PG classification | NA |
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