Gene Information
Gene NameTKT
OrganismHomo sapiens (Human)
Gene Length855
Protein NamesDiscoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Target Nametransketolase
Target TypeNA
Gene Age454 ( ENSG00000163931 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ16832
Gene CardDDR2
Uniprot IDQ16832
PfamPF00754; PF07714
In ASDyes
Allosteric Predictionyes (0.673782811)
Ortholog in AnimalsAlpaca_ TKT ( ortholog_one2one )
Dog_ TKT ( ortholog_one2one )
GuineaPig_ TKT ( ortholog_one2one )
Macaque_ TKT ( ortholog_one2one )
Mouse_ Tkt ( ortholog_one2one )
Pig_ TKT ( ortholog_one2one )
Rat_ Tkt ( ortholog_one2one )
Rabbit_ TKT ( ortholog_one2one )
OhnologsTKTL1, TKTL2
ParalogsBCKDHB, PDHB, TKTL2, TKTL1
TissueNA
Tissue SpecificityDetected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. {ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:8247548}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2WUH  (X-ray  1.60A  2Z4F  (NMR  6FER  (X-ray  2.87A  7AZB  (X-ray  2.62A 
DBSNP rs397514747  rs34722354  rs34869543  rs55973200  rs121964865  rs121964864  rs121964863 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899};
Single-pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}.
Mouse PG classificationNA
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