Gene Information | |
---|---|
Gene Name | TKT |
Organism | Homo sapiens (Human) |
Gene Length | 855 |
Protein Names | Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b) |
Target Name | transketolase |
Target Type | NA |
Gene Age | 454 ( ENSG00000163931 ) |
Evolutionary Stage | Euk+Bac |
AlphaFoldDB | Q16832 |
Gene Card | DDR2 |
Uniprot ID | Q16832 |
Pfam | PF00754; PF07714 |
In ASD | yes |
Allosteric Prediction | yes (0.673782811) |
Ortholog in Animals | Alpaca_ TKT ( ortholog_one2one ) Dog_ TKT ( ortholog_one2one ) GuineaPig_ TKT ( ortholog_one2one ) Macaque_ TKT ( ortholog_one2one ) Mouse_ Tkt ( ortholog_one2one ) Pig_ TKT ( ortholog_one2one ) Rat_ Tkt ( ortholog_one2one ) Rabbit_ TKT ( ortholog_one2one ) |
Ohnologs | TKTL1, TKTL2 |
Paralogs | BCKDHB, PDHB, TKTL2, TKTL1 |
Tissue | NA |
Tissue Specificity | Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. {ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:8247548}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 2WUH (X-ray 1.60A ) 2Z4F (NMR - ) 6FER (X-ray 2.87A ) 7AZB (X-ray 2.62A ) |
DBSNP | rs397514747 rs34722354 rs34869543 rs55973200 rs121964865 rs121964864 rs121964863 |
Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}; Single-pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}. |
Mouse PG classification | NA |
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