| Gene Information | |
|---|---|
| Gene Name | TKF |
| Organism | Homo sapiens (Human) |
| Gene Length | 802 |
| Protein Names | Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P22455 |
| Gene Card | FGFR4 |
| Uniprot ID | P22455 |
| Pfam | PF07679; PF07714 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. {ECO:0000269|PubMed:10631118}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4QQ5 (X-ray 2.20A ) 4QQC (X-ray 2.40A ) 4QQJ (X-ray 1.68A ) 4QQT (X-ray 1.50A ) 4QRC (X-ray 1.90A ) 4R6V (X-ray 2.35A ) 4TYE (X-ray 2.80A ) 4TYG (X-ray 2.40A ) 4TYI (X-ray 3.40A ) 4TYJ (X-ray 2.45A ) 4UXQ (X-ray 1.85A ) 4XCU (X-ray 1.71A ) 5JKG (X-ray 2.35A ) 5NUD (X-ray 2.50A ) 5NWZ (X-ray 2.37A ) 5XFF (X-ray 2.70A ) 5XFJ (X-ray 3.25A ) 6IUO (X-ray 2.30A ) 6IUP (X-ray 2.00A ) 6J6Y (X-ray 2.15A ) 6JPE (X-ray 1.60A ) 6JPJ (X-ray 2.64A ) 6NVG (X-ray 1.99A ) 6NVH (X-ray 1.90A ) 6NVI (X-ray 2.12A ) 6NVJ (X-ray 2.30A ) 6NVK (X-ray 2.30A ) 6V9C (X-ray 1.90A ) 6YI8 (X-ray 2.13A ) 7DTZ (X-ray 2.01A ) 7F3M (X-ray 2.29A ) 7N1J (X-ray 2.99A ) 7V29 (X-ray 1.98A ) 7VJL (X-ray 2.90A ) 7WCT (X-ray 2.11A ) 7WCW (X-ray 2.32A ) 7WCX (X-ray 2.17A ) |
| DBSNP | rs1966265 rs376618 rs55675160 rs351855 rs55879131 rs34158682 rs34284947 rs774571806 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; [Isoform 2]: Secreted. |
| Mouse PG classification | NA |
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