| Gene Information | |
|---|---|
| Gene Name | TJP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1190 |
| Protein Names | Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000119139 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9UDY2 |
| Gene Card | TJP2 |
| Uniprot ID | Q9UDY2 |
| Pfam | PF00625; PF00595; PF07653 |
| In ASD | no |
| Allosteric Prediction | yes (0.793916895) |
| Ortholog in Animals | Alpaca_ TJP2 ( ortholog_one2one ) Dog_ TJP2 ( ortholog_one2one ) GuineaPig_ TJP2 ( ortholog_one2one ) Macaque_ TJP2 ( ortholog_one2one ) Mouse_ Tjp2 ( ortholog_one2one ) Pig_ TJP2 ( ortholog_one2one ) Rat_ Tjp2 ( ortholog_one2one ) Rabbit_ TJP2 ( ortholog_one2one ) |
| Ohnologs | TJP1, TJP3 |
| Paralogs | DLG5, TJP3, TJP1 |
| Tissue | NA |
| Tissue Specificity | This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. {ECO:0000269|PubMed:11018256}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2OSG (NMR - ) 3E17 (X-ray 1.75A ) |
| DBSNP | rs121918299 rs2309428 rs34774441 rs35797487 rs1049624 rs1049625 |
| Subcellular location [CC] | Cell junction, adherens junction. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z0U1}. Nucleus {ECO:0000250}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. {ECO:0000250}. |
| Mouse PG classification | LPG |
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