| Gene Information | |
|---|---|
| Gene Name | TJP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1748 |
| Protein Names | Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000104067 ) 3 ( ENSG00000277401 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q07157 |
| Gene Card | TJP1 |
| Uniprot ID | Q07157 |
| Pfam | PF00625; PF00595; PF07653; PF00791 |
| In ASD | no |
| Allosteric Prediction | yes (0.380739893) |
| Ortholog in Animals | Alpaca_ TJP1 ( ortholog_one2one ) Dog_ TJP1 ( ortholog_one2one ) GuineaPig_ TJP1 ( ortholog_one2one ) Macaque_ TJP1 ( ortholog_one2one ) Mouse_ Tjp1 ( ortholog_one2one ) Pig_ TJP1 ( ortholog_one2one ) Rat_ Tjp1 ( ortholog_one2one ) Rabbit_ TJP1 ( ortholog_one2one ) |
| Ohnologs | TJP3, TJP2 |
| Paralogs | DLG5, TJP2, TJP3 |
| Tissue | substantia.nigra |
| Tissue Specificity | The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2H2B (X-ray 1.60A ) 2H2C (X-ray 2.00A ) 2H3M (X-ray 2.90A ) 2JWE (NMR - ) 2KXR (NMR - ) 2KXS (NMR - ) 2RCZ (X-ray 1.70A ) 3CYY (X-ray 2.40A ) 3LH5 (X-ray 2.60A ) 3SHU (X-ray 2.75A ) 3SHW (X-ray 2.90A ) 3TSV (X-ray 1.99A ) 3TSW (X-ray 2.85A ) 3TSZ (X-ray 2.50A ) 4OEO (X-ray 1.90A ) 4OEP (X-ray 2.35A ) 4Q2Q (X-ray 1.45A ) 4YYX (X-ray 1.79A ) |
| DBSNP | rs2229517 rs2229515 rs45529137 rs45567033 rs2291166 rs45578638 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:7798316}; Peripheral membrane protein {ECO:0000269|PubMed:7798316}; Cytoplasmic side {ECO:0000269|PubMed:7798316}. Cell junction, tight junction {ECO:0000269|PubMed:7798316}. Cell junction {ECO:0000269|PubMed:28169360}. Cell junction, gap junction. Cell projection, podosome {ECO:0000269|PubMed:20930113}. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:31473225, ECO:0000269|PubMed:7798316}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |