| Gene Information | |
|---|---|
| Gene Name | TIS11B |
| Organism | Homo sapiens (Human) |
| Gene Length | 338 |
| Protein Names | mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q07352 |
| Gene Card | ZFP36L1 |
| Uniprot ID | Q07352 |
| Pfam | PF04553; PF00642 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005). {ECO:0000269|PubMed:15465005, ECO:0000269|PubMed:27182009}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1W0V (X-ray 2.27A ) 1W0W (X-ray 2.11A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12198173}. Cytoplasm {ECO:0000269|PubMed:12198173}. Cytoplasmic granule {ECO:0000269|PubMed:15967811}. Cytoplasm, P-body {ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17369404}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Component of cytoplasmic stress granules (PubMed:15967811). Localizes in processing bodies (PBs) (PubMed:17369404). {ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17369404}. |
| Mouse PG classification | NA |
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