Gene Information
Gene NameTIS11A
OrganismHomo sapiens (Human)
Gene Length326
Protein NamesmRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP26651
Gene CardZFP36
Uniprot IDP26651
PfamPF00642
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in both basal and suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (PubMed:27182009). Expressed strongly in mature dendritic cells (PubMed:18367721). Expressed in immature dendritic cells (at protein level) (PubMed:18367721). {ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:27182009}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.011111(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4J8S  (X-ray  1.55A  ) 
DBSNP rs17878633  rs2229272  rs17886974  rs17884899 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:27182009}. Cytoplasm {ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:14766228, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:20221403}. Cytoplasmic granule {ECO:0000269|PubMed:15014438}. Cytoplasm, P-body {ECO:0000269|PubMed:17369404}. Note=Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (By similarity). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (By similarity). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (PubMed:20221403). Component of cytoplasmic stress granules (SGs) (By similarity). Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438). Localizes in processing bodies (PBs) (PubMed:17369404). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (By similarity). Shuttles in and out of both cytoplasmic P-body and SGs (By similarity). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:20221403}.;
Nucleus {ECO:0000269|PubMed:14679154}. Cytoplasm {ECO:0000269|PubMed:14679154}. Note=(Microbial infection) Colocalizes with HTLV-1 TAX in the nucleus and the cytoplasm in a region surrounding the nucleus. {ECO:0000269|PubMed:14679154}.
Mouse PG classificationNA
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