| Gene Information | |
|---|---|
| Gene Name | KRT81 |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Keratin, type II cuticular Hb1 (Hair keratin K2.9) (Keratin, hair, basic, 1) (Keratin-81) (K81) (Metastatic lymph node 137 gene protein) (MLN 137) (Type II hair keratin Hb1) (Type-II keratin Kb21) (ghHKb1) (ghHb1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 86 ( ENSG00000205426 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14533 |
| Gene Card | KRT81 |
| Uniprot ID | Q14533 |
| Pfam | PF00038; PF16208 |
| In ASD | no |
| Allosteric Prediction | no (-1.290873237) |
| Ortholog in Animals | Alpaca_ KRT81 ( ortholog_one2one ) Dog_ KRT85 ( ortholog_one2many ) Macaque_ KRT81 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KRT86, KRT83, VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue. {ECO:0000269|PubMed:7490069, ECO:0000269|PubMed:7528047, ECO:0000269|PubMed:9457912}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2071588 rs6580873 rs4761786 rs56821304 rs771393943 rs57419521 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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