| Gene Information | |
|---|---|
| Gene Name | TIFA |
| Organism | Homo sapiens (Human) |
| Gene Length | 184 |
| Protein Names | TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000145365 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96CG3 |
| Gene Card | TIFA |
| Uniprot ID | Q96CG3 |
| Pfam | PF00498 |
| In ASD | no |
| Allosteric Prediction | no (-1.361277704) |
| Ortholog in Animals | Alpaca_ TIFA ( ortholog_one2one ) Dog_ TIFA ( ortholog_one2one ) GuineaPig_ TIFA ( ortholog_one2one ) Macaque_ TIFA ( ortholog_one2one ) Mouse_ Tifa ( ortholog_one2one ) Pig_ TIFA ( ortholog_one2one ) Rat_ Tifa ( ortholog_one2one ) Rabbit_ TIFA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TIFAB |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4YM4 (X-ray 3.12A ) 4ZGI (X-ray 2.70A ) 5ZUJ (X-ray 2.60A ) 6A33 (X-ray 2.10A ) |
| DBSNP | rs6834237 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22566686, ECO:0000305|PubMed:26068852}. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. {ECO:0000269|PubMed:26068852}. |
| Mouse PG classification | NA |
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