| Gene Information | |
|---|---|
| Gene Name | CLDN7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 211 |
| Protein Names | Claudin-7 (CLDN-7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000181885 ) 3 ( ENSG00000288292 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95471 |
| Gene Card | CLDN7 |
| Uniprot ID | O95471 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | no (-0.78808261) |
| Ortholog in Animals | Alpaca_ CLDN7 ( ortholog_one2one ) Dog_ CLDN7 ( ortholog_one2one ) GuineaPig_ CLDN7 ( ortholog_one2one ) Macaque_ CLDN7 ( ortholog_one2one ) Mouse_ Cldn7 ( ortholog_one2one ) Pig_ CLDN7 ( ortholog_one2one ) Rat_ Cldn7 ( ortholog_one2one ) Rabbit_ CLDN7 ( ortholog_one2one ) |
| Ohnologs | CLDN5, CLDN18, CLDN10, CLDN19, CLDN6, CLDN9 |
| Paralogs | CLDN1, CLDN5, CLDN8, CLDN3, CLDN20, CLDN11, CLDN14, CLDN18, CLDN10, CLDN9, CLDN17, CLDN24, CLDN22, CLDN23, CLDN4, CLDN15, CLDN19, CLDN34, CLDN2, CLDN25, CLDN16, CLDN6 |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. {ECO:0000269|PubMed:12673207, ECO:0000269|PubMed:14502431}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17849410 rs4562 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12673207, ECO:0000269|PubMed:14502431, ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Co-localizes with EPCAM at the basolateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}. |
| Mouse PG classification | NA |
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