| Gene Information | |
|---|---|
| Gene Name | TIE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1124 |
| Protein Names | Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q02763 |
| Gene Card | TEK |
| Uniprot ID | Q02763 |
| Pfam | PF00041; PF10430; PF07714 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney. {ECO:0000269|PubMed:11806244, ECO:0000269|PubMed:8382358}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.027573(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1FVR (X-ray 2.20A ) 2GY5 (X-ray 2.90A ) 2GY7 (X-ray 3.70A ) 2OO8 (X-ray 2.20A ) 2OSC (X-ray 2.80A ) 2P4I (X-ray 2.50A ) 2WQB (X-ray 2.95A ) 3BEA (X-ray 2.02A ) 3L8P (X-ray 2.40A ) 4K0V (X-ray 4.51A ) 4X3J (X-ray 2.50A ) 5MYA (X-ray 2.90A ) 5MYB (X-ray 2.60A ) 5UTK (X-ray 2.50A ) 6MWE (X-ray 2.05A ) 7E72 (X-ray 2.09A ) |
| DBSNP | rs35969327 rs35814893 rs146169480 rs682632 rs34032300 rs1334811 rs35030851 rs1306527531 rs35378598 rs56367117 rs4631561 rs80338908 rs1490428165 rs80338909 rs80338909 rs1825682849 rs1825682922 rs387906745 rs1825683100 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19079259, ECO:0000269|PubMed:27270174}; Single-pass type I membrane protein. Cell junction {ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:27270174}. Cell junction, focal adhesion {ECO:0000305|PubMed:19293632}. Cytoplasm, cytoskeleton. Secreted {ECO:0000269|PubMed:11806244}. Note=Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244). {ECO:0000269|PubMed:11806244, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120}. |
| Mouse PG classification | NA |
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