| Gene Information | |
|---|---|
| Gene Name | TIAM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1591 |
| Protein Names | Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000156299 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q13009 |
| Gene Card | TIAM1 |
| Uniprot ID | Q13009 |
| Pfam | PF00595; PF00169; PF02196; PF00621; PF18385 |
| In ASD | no |
| Allosteric Prediction | yes (0.958122286) |
| Ortholog in Animals | Alpaca_ TIAM1 ( ortholog_one2one ) Dog_ TIAM1 ( ortholog_one2one ) GuineaPig_ TIAM1 ( ortholog_one2one ) Macaque_ TIAM1 ( ortholog_one2one ) Mouse_ Tiam1 ( ortholog_one2one ) Pig_ TIAM1 ( ortholog_one2one ) Rat_ Tiam1 ( ortholog_one2one ) Rabbit_ TIAM1 ( ortholog_one2one ) |
| Ohnologs | TIAM2 |
| Paralogs | MCF2L2, VAV1, PLEKHN1, PLEKHG4, TIAM2, ARHGEF40, ARHGEF25, VAV2, VAV3, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | cerebellum |
| Tissue Specificity | Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2D8I (NMR - ) 3KZD (X-ray 1.30A ) 3KZE (X-ray 1.80A ) 4GVC (X-ray 1.54A ) 4GVD (X-ray 1.85A ) 4K2O (X-ray 2.15A ) 4K2P (X-ray 1.98A ) 4NXP (X-ray 2.30A ) 4NXQ (X-ray 2.10A ) 4NXR (X-ray 1.90A ) |
| DBSNP | rs2070418 rs2070417 rs1192824496 rs16987932 rs77092908 rs75483199 rs1319513413 |
| Subcellular location [CC] | Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}. |
| Mouse PG classification | NA |
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