| Gene Information | |
|---|---|
| Gene Name | THW |
| Organism | Homo sapiens (Human) |
| Gene Length | 193 |
| Protein Names | p53 apoptosis effector related to PMP-22 (Keratinocyte-associated protein 1) (KCP-1) (P53-induced protein PIGPC1) (Transmembrane protein THW) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96FX8 |
| Gene Card | PERP |
| Uniprot ID | Q96FX8 |
| Pfam | PF00822 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts. {ECO:0000269|PubMed:12752121}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs648802 rs75183345 |
| Subcellular location [CC] | Cell junction, desmosome {ECO:0000250|UniProtKB:Q9JK95}. Cell membrane {ECO:0000269|PubMed:30321533, ECO:0000269|PubMed:31898316}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane (PubMed:31898316). {ECO:0000250|UniProtKB:Q9JK95, ECO:0000269|PubMed:31898316}. |
| Mouse PG classification | NA |
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