Gene Information
Gene NameATM
OrganismHomo sapiens (Human)
Gene Length3056
Protein NamesSerine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Target Nameatm serine/threonine kinase
Target TypeClinical trial target
Gene Age1064 ( ENSG00000149311 )
Evolutionary StageEukaryota
AlphaFoldDBNA
Gene CardATM
Uniprot IDQ13315
PfamPF02259; PF02260; PF00454; PF11640
In ASDno
Allosteric Predictionyes (0.701054605)
Ortholog in AnimalsAlpaca_ ATM ( ortholog_one2one )
Dog_ ATM ( ortholog_one2one )
GuineaPig_ ATM ( ortholog_one2one )
Macaque_ ATM ( ortholog_one2one )
Mouse_ Atm ( ortholog_one2one )
Pig_ ATM ( ortholog_one2one )
Rat_ Atm ( ortholog_one2one )
Rabbit_ ATM ( ortholog_one2one )
OhnologsNA
ParalogsTRRAP, SMG1, ATR, PRKDC, MTOR
TissueNA
Tissue SpecificityFound in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.418674(Rat);0.091179(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5NP0  (EM  5.70A  )  5NP1  (EM  5.70A  )  6HKA  (NMR  -  )  6K9K  (EM  7.82A  )  6K9L  (EM  4.27A  )  7NI4  (EM  3.00A  )  7NI5  (EM  2.78A  )  7NI6  (EM  2.80A  )  7SIC  (EM  2.51A  )  7SID  (EM  2.53A  ) 
DBSNP rs587779858  rs55861249  rs3218684  rs1800054  rs2234997  rs55633650  rs3218707  rs145053092  rs56123940  rs747727055  rs587781511  rs28904919  rs138398778  rs202160435  rs371713984  rs369203092  rs587776547  rs56128736  rs56365018  rs2235000  rs2227924  rs777301065  rs2235006  rs4986761  rs2235011  rs587778065  rs641252  rs3218695  rs879254046  rs1800056  rs3218673  rs55723361  rs35813135  rs3218708  rs3218688  rs786203054  rs3092857  rs568461905  rs1800057  rs3092841  rs35184530  rs144535256  rs3092856  rs55859590  rs1234250980  rs1800058  rs2229021  rs730881391  rs730881369  rs775047783  rs34640941  rs3092849  rs140856217  rs55870064  rs121434217  rs1800059  rs3092907  rs764389018  rs587779844  rs1801516  rs1801673  rs1060501688  rs56399311  rs659243  rs587782274  rs587781302  rs11212587  rs3218670  rs866290641  rs397514577  rs1555114558  rs1800060  rs1064795467  rs1317619286  rs564652222  rs567060474  rs1800061  rs56009889  rs4988111  rs3092831  rs876658517  rs370559102  rs730881315  rs121434221  rs28904921  rs147604227  rs587782310  rs55801750  rs876659365  rs56399857  rs587776547  rs28904920  rs267606668  rs1196903858  rs267606669  rs4988125  rs121434218  rs1471563800  rs745775382  rs876659735  rs3218680  rs55982963  rs1555128314  rs876659619  rs748634900  rs876660927  rs121434216  rs938431501  rs587779872  rs879254065  rs587778080  rs587782202  rs587781353  rs780905851  rs55798854  rs587779874  rs786202826  rs1137889  rs876658767  rs587782292  rs587781894 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358}. Cytoplasmic vesicle {ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q62388}. Peroxisome matrix {ECO:0000269|PubMed:26344566}. Note=Primarily nuclear (PubMed:9050866, PubMed:9150358). Found also in endocytic vesicles in association with beta-adaptin (PubMed:9707615). Translocated to peroxisomes in response to reactive oxygen species (ROS) by PEX5 (PubMed:26344566). {ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:9050866, ECO:0000269|PubMed:9150358, ECO:0000269|PubMed:9707615}.
Mouse PG classificationNA
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