| Gene Information | |
|---|---|
| Gene Name | THRB |
| Organism | Homo sapiens (Human) |
| Gene Length | 461 |
| Protein Names | Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta) |
| Target Name | thyroid hormone receptor beta |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000151090 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10828 |
| Gene Card | THRB |
| Uniprot ID | P10828 |
| Pfam | PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (0.69208014) |
| Ortholog in Animals | Alpaca_ THRB ( ortholog_one2one ) Dog_ THRB ( ortholog_one2one ) GuineaPig_ THRB ( ortholog_one2one ) Macaque_ THRB ( ortholog_one2one ) Mouse_ Thrb ( ortholog_one2one ) Pig_ THRB ( ortholog_one2one ) Rat_ Thrb ( ortholog_one2one ) Rabbit_ THRB ( ortholog_one2one ) |
| Ohnologs | THRA |
| Paralogs | NR1H4, VDR, RARG, NR1D2, RARA, PPARD, NR1H2, RORC, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA, THRA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BSX (X-ray 3.70A ) 1N46 (X-ray 2.20A ) 1NAX (X-ray 2.70A ) 1NQ0 (X-ray 2.40A ) 1NQ1 (X-ray 2.90A ) 1NQ2 (X-ray 2.40A ) 1NUO (X-ray 3.10A ) 1Q4X (X-ray 2.80A ) 1R6G (X-ray 3.00A ) 1XZX (X-ray 2.50A ) 1Y0X (X-ray 3.10A ) 2J4A (X-ray 2.20A ) 2NLL (X-ray 1.90A ) 2PIN (X-ray 2.30A ) 3D57 (X-ray 2.20A ) 3GWS (X-ray 2.20A ) 3IMY (X-ray 2.55A ) 3JZC (X-ray 2.50A ) 4ZO1 (X-ray 3.22A ) 6KKB (X-ray 1.70A ) 6KKE (X-ray 2.58A ) 6KNU (X-ray 2.70A ) 6KNV (X-ray 2.80A ) 6KNW (X-ray 2.67A ) 7WLX (X-ray 2.39A ) 7WMG (X-ray 2.93A ) 7WMH (X-ray 1.97A ) 7WMJ (X-ray 2.81A ) 7WML (X-ray 2.67A ) 7WMN (X-ray 2.57A ) 7WMO (X-ray 2.56A ) |
| DBSNP | rs9865746 rs121918694 rs121918707 rs121918695 rs121918690 rs121918696 rs121918693 rs28999969 rs1054624 rs121918697 rs121918688 rs121918686 rs121918686 rs28999970 rs28999971 rs1553609210 rs1553609195 rs121918698 rs121918691 rs121918692 rs121918703 rs121918687 rs28933408 rs28933408 rs121918702 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | HPG |
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