| Gene Information | |
|---|---|
| Gene Name | THRA |
| Organism | Homo sapiens (Human) |
| Gene Length | 490 |
| Protein Names | Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha) |
| Target Name | thyroid hormone receptor alpha |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000126351 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10827 |
| Gene Card | THRA |
| Uniprot ID | P10827 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (0.562651688) |
| Ortholog in Animals | Alpaca_ THRA ( ortholog_one2one ) Dog_ THRA ( ortholog_one2one ) GuineaPig_ THRA ( ortholog_one2one ) Macaque_ THRA ( ortholog_one2one ) Mouse_ Thra ( ortholog_one2one ) Pig_ THRA ( ortholog_one2one ) Rat_ Thra ( ortholog_one2one ) Rabbit_ THRA ( ortholog_one2one ) |
| Ohnologs | THRB |
| Paralogs | NR1H4, VDR, RARG, NR1D2, RARA, PPARD, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NAV (X-ray 2.50A ) 2H77 (X-ray 2.33A ) 2H79 (X-ray 1.87A ) 3HZF (X-ray 2.50A ) 3ILZ (X-ray 1.85A ) 3JZB (X-ray 2.01A ) 4LNW (X-ray 1.90A ) 4LNX (X-ray 2.05A ) 7QDT (X-ray 3.00A ) |
| DBSNP | rs1555545033 |
| Subcellular location [CC] | Nucleus.; [Isoform Alpha-2]: Cytoplasm {ECO:0000250|UniProtKB:P63058}. Nucleus {ECO:0000250|UniProtKB:P63058}. Note=When overexpressed found in the cytoplasm where it colocalizes with TACC1. {ECO:0000250|UniProtKB:P63058}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |