Gene Information
Gene NameCAMSAP2
OrganismHomo sapiens (Human)
Gene Length1489
Protein NamesCalmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000118200 )
Evolutionary StageEumetazoa
AlphaFoldDBQ08AD1
Gene CardCAMSAP2
Uniprot IDQ08AD1
PfamPF17095; PF11971; PF08683
In ASDno
Allosteric Predictionyes (0.358536931)
Ortholog in AnimalsAlpaca_ CAMSAP2 ( ortholog_one2one )
Dog_ CAMSAP2 ( ortholog_one2one )
GuineaPig_ CAMSAP2 ( ortholog_one2one )
Macaque_ CAMSAP2 ( ortholog_one2one )
Mouse_ Camsap2 ( ortholog_one2one )
Pig_ CAMSAP2 ( ortholog_one2one )
Rat_ Camsap2 ( ortholog_one2one )
Rabbit_ CAMSAP2 ( ortholog_one2one )
OhnologsCAMSAP3, CAMSAP1
ParalogsCAMSAP3, CAMSAP1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3753952  rs3753952  rs6674599  rs6674599 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:24908486, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570}. Golgi apparatus {ECO:0000269|PubMed:27666745}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8C1B1}. Cytoplasm {ECO:0000250|UniProtKB:Q8C1B1}. Note=Associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:23169647, PubMed:24486153, PubMed:24908486, PubMed:24706919, PubMed:27666745, PubMed:28814570). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). The length of CAMSAP2-decorated stretches on the minus-end of microtubules depends on MAPRE1/EB1 and MAPRE3/EB3, which promote elongation of CAMSAP2-decorated microtubule stretches (PubMed:28814570). Recruited to the Golgi apparatus by AKAP9 and PDE4DIP isoform 13/MMG8/SMYLE (PubMed:27666745). In neurons, localizes to the minus-end of microtubules in axon and dendrites (PubMed:24908486). {ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:24706919, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570}.
Mouse PG classificationNA
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