| Gene Information | |
|---|---|
| Gene Name | LAMA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3333 |
| Protein Names | Laminin subunit alpha-3 (Epiligrin 170 kDa subunit) (E170) (Epiligrin subunit alpha) (Kalinin subunit alpha) (Laminin-5 subunit alpha) (Laminin-6 subunit alpha) (Laminin-7 subunit alpha) (Nicein subunit alpha) |
| Target Name | laminin subunit alpha-3 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000053747 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | LAMA3 |
| Uniprot ID | Q16787 |
| Pfam | PF00052; PF00053; PF02210; PF06008; PF06009; PF00055 |
| In ASD | no |
| Allosteric Prediction | no (-0.100978538) |
| Ortholog in Animals | Alpaca_ LAMA3 ( ortholog_one2one ) Dog_ LAMA3 ( ortholog_one2one ) GuineaPig_ LAMA3 ( ortholog_one2one ) Macaque_ LAMA3 ( ortholog_one2one ) Mouse_ Lama3 ( ortholog_one2one ) Pig_ LAMA3 ( ortholog_one2one ) Rat_ Lama3 ( ortholog_one2one ) Rabbit_ LAMA3 ( ortholog_one2one ) |
| Ohnologs | LAMA5 |
| Paralogs | LAMB2, LAMC3, NTN4, LAMB1, LAMC1, ATRNL1, LAMA2, TMEFF2, ATRN, NTN1, NTN3, LAMC2, TMEFF1, LAMA1, AGRN, LAMB4, NTNG2, NTNG1, LAMA4, MEGF9, MEGF8, LAMB3, EGFLAM, LAMA5, NTN5, USH2A, HSPG2 |
| Tissue | NA |
| Tissue Specificity | Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS. |
| Pharmacological Animal Models | 0.017880(Chimpanzee);0.001000(Mouse);NULL(Rat);0.102857(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs17187262 rs12457323 rs17202961 rs958631 rs9952370 rs1154232 rs1154233 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
| Mouse PG classification | HPG |
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