| Gene Information | |
|---|---|
| Gene Name | TH |
| Organism | Homo sapiens (Human) |
| Gene Length | 528 |
| Protein Names | Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) |
| Target Name | tyrosine 3-monooxygenase |
| Target Type | Successful target |
| Gene Age | 810 ( ENSG00000180176 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P07101 |
| Gene Card | TH |
| Uniprot ID | P07101 |
| Pfam | PF00351; PF12549 |
| In ASD | no |
| Allosteric Prediction | yes (0.664138469) |
| Ortholog in Animals | Alpaca_ TH ( ortholog_one2one ) Dog_ TH ( ortholog_one2one ) GuineaPig_ TH ( ortholog_one2one ) Macaque_ TH ( ortholog_one2one ) Mouse_ Th ( ortholog_one2one ) Pig_ TH ( ortholog_one2one ) Rat_ Th ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PAH, TPH1, TPH2 |
| Tissue | adrenal.gland, locus.ceruleus, substantia.nigra |
| Tissue Specificity | Mainly expressed in the brain and adrenal glands. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XSN (X-ray 2.68A ) 4J6S (X-ray 3.08A ) 6ZN2 (EM 4.30A ) 6ZVP (EM 4.00A ) 6ZZU (EM 3.50A ) 7A2G (EM 4.10A ) 7PIM (EM 4.60A ) |
| DBSNP | rs766704202 rs6356 rs80338892 rs121917763 rs1260455415 rs762304556 rs28934581 rs1273610334 rs755536257 rs199961079 rs121917764 rs1288483479 rs1428589694 rs28934580 rs121917765 rs763198914 rs1554922725 rs763039181 rs1057520384 rs745551241 rs121917762 rs370962049 rs1264884607 rs367874223 rs767635052 rs45471299 rs771351747 rs1800033 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P24529}. Nucleus {ECO:0000250|UniProtKB:P04177}. Cell projection, axon {ECO:0000250|UniProtKB:P24529}. Cytoplasm {ECO:0000250|UniProtKB:P04177}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P04177}. Note=When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals. {ECO:0000250|UniProtKB:P04177}. |
| Mouse PG classification | NA |
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