| Gene Information | |
|---|---|
| Gene Name | TGS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 853 |
| Protein Names | Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000137574 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96RS0 |
| Gene Card | TGS1 |
| Uniprot ID | Q96RS0 |
| Pfam | PF09445 |
| In ASD | no |
| Allosteric Prediction | yes (0.121880235) |
| Ortholog in Animals | Alpaca_ TGS1 ( ortholog_one2one ) Dog_ TGS1 ( ortholog_one2one ) GuineaPig_ TGS1 ( ortholog_one2one ) Macaque_ TGS1 ( ortholog_one2one ) Mouse_ Tgs1 ( ortholog_one2one ) Pig_ TGS1 ( ortholog_one2one ) Rat_ Tgs1 ( ortholog_one2one ) Rabbit_ TGS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:11517327}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.015385(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3EGI (X-ray 2.21A ) 3GDH (X-ray 2.00A ) |
| DBSNP | rs1818 rs3213971 rs11986329 rs10100659 rs16922259 rs10109493 rs7823773 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12943661}. Nucleus, Cajal body {ECO:0000305|PubMed:12032086}. Nucleus, nucleolus {ECO:0000269|PubMed:12032086}. Note=A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network. {ECO:0000269|PubMed:12943661}. |
| Mouse PG classification | NA |
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