Gene Information
Gene NameTGM1
OrganismHomo sapiens (Human)
Gene Length817
Protein NamesProtein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000092295 )
3 ( ENSG00000285348 )
Evolutionary StageEumetazoa
AlphaFoldDBP22735
Gene CardTGM1
Uniprot IDP22735
PfamPF00927; PF01841; PF00868
In ASDno
Allosteric Predictionno (-0.682944689)
Ortholog in AnimalsAlpaca_ TGM1 ( ortholog_one2one )
Dog_ TGM1 ( ortholog_one2one )
GuineaPig_ TGM1 ( ortholog_one2one )
Macaque_ TGM1 ( ortholog_one2one )
Mouse_ Tgm1 ( ortholog_one2one )
Pig_ TGM1 ( ortholog_one2one )
Rat_ Tgm1 ( ortholog_one2one )
Rabbit_ TGM1 ( ortholog_one2one )
OhnologsTGM3, F13A1, TGM4
ParalogsF13A1, TGM6, TGM4, EPB42, TGM2, TGM3, TGM5, TGM7
Tissueesophagus, esophagus.mucosa
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2XZZ  (X-ray  2.30A  ) 
DBSNP rs41295338  rs121918729  rs398122901  rs397514524  rs200491579  rs2229462  rs147916609  rs121918716  rs121918718  rs531650682  rs121918719  rs1465243895  rs778635368  rs121918728  rs878853259  rs1555306304  rs121918732  rs549195122  rs549195122  rs781006633  rs201868387  rs764040146  rs397514523  rs121918725  rs749721551  rs121918727  rs121918730  rs753798494  rs121918731  rs121918731  rs397514525  rs143473912  rs143473912  rs121918717  rs771820315  rs779287673  rs202037016  rs41293794  rs121918720  rs121918722  rs121918723  rs121918723  rs121918726  rs121918721  rs121918721  rs991194429  rs1555306103  rs1057517838  rs121918724  rs35312232  rs142404759  rs1044429462  rs2229464  rs147516124  rs35926651  rs201853046  rs2228337 
Subcellular location [CC]Membrane {ECO:0000269|PubMed:17762858};
Lipid-anchor {ECO:0000305|PubMed:17762858}.
Mouse PG classificationHPG
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