| Gene Information | |
|---|---|
| Gene Name | TGFBR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 503 |
| Protein Names | TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) |
| Target Name | tgf-beta receptor type i |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000106799 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P36897 |
| Gene Card | TGFBR1 |
| Uniprot ID | P36897 |
| Pfam | PF01064; PF00069; PF08515 |
| In ASD | no |
| Allosteric Prediction | yes (0.751378454) |
| Ortholog in Animals | Alpaca_ TGFBR1 ( ortholog_one2one ) Dog_ TGFBR1 ( ortholog_one2one ) GuineaPig_ TGFBR1 ( ortholog_one2one ) Macaque_ TGFBR1 ( ortholog_one2one ) Mouse_ Tgfbr1 ( ortholog_one2one ) Pig_ TGFBR1 ( ortholog_one2one ) Rat_ Tgfbr1 ( ortholog_one2one ) Rabbit_ TGFBR1 ( ortholog_one2one ) |
| Ohnologs | ACVR1B, ACVR1C |
| Paralogs | ACVR1, BMPR2, ACVR2A, TGFBR2, ACVR2B, BMPR1A, AMHR2, ACVR1B, BMPR1B, ACVRL1, ACVR1C |
| Tissue | NA |
| Tissue Specificity | Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292). {ECO:0000269|PubMed:25893292}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002166(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B6C (X-ray 2.60A ) 1IAS (X-ray 2.90A ) 1PY5 (X-ray 2.30A ) 1RW8 (X-ray 2.40A ) 1VJY (X-ray 2.00A ) 2L5S (NMR - ) 2PJY (X-ray 3.00A ) 2WOT (X-ray 1.85A ) 2WOU (X-ray 2.30A ) 2X7O (X-ray 3.70A ) 3FAA (X-ray 3.35A ) 3GXL (X-ray 1.80A ) 3HMM (X-ray 1.70A ) 3KCF (X-ray 2.80A ) 3KFD (X-ray 3.00A ) 3TZM (X-ray 1.70A ) 4X0M (X-ray 1.68A ) 4X2F (X-ray 1.49A ) 4X2G (X-ray 1.51A ) 4X2J (X-ray 1.69A ) 4X2K (X-ray 1.69A ) 4X2N (X-ray 1.80A ) 5E8S (X-ray 1.45A ) 5E8T (X-ray 1.70A ) 5E8U (X-ray 2.03A ) 5E8W (X-ray 1.86A ) 5E8X (X-ray 1.45A ) 5E8Z (X-ray 1.51A ) 5E90 (X-ray 2.05A ) 5FRI (X-ray 2.00A ) 5QIK (X-ray 1.58A ) 5QIL (X-ray 1.98A ) 5QIM (X-ray 1.75A ) 5QTZ (X-ray 1.83A ) 5QU0 (X-ray 1.67A ) 5USQ (X-ray 2.55A ) 6B8Y (X-ray 1.65A ) 6MAC (X-ray 2.34A ) |
| DBSNP | rs387906696 rs587776865 rs757374917 rs148176750 rs56014374 rs121918712 rs111854391 rs35974499 rs121918710 rs1827743139 rs121918711 rs113605875 rs113605875 rs111426349 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:9472030}; Single-pass type I membrane protein {ECO:0000269|PubMed:9472030}. Cell junction, tight junction {ECO:0000269|PubMed:15761148}. Cell surface {ECO:0000269|PubMed:25893292}. Membrane raft {ECO:0000269|PubMed:25893292}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |